|Open-source genomics on your computer and in your garage! In recent years, collaborative scientific efforts such as the Human Genome Project, have generate a wealth of information about the genome of humans and other organisms. Most of this information is now publicly available online. As the role of 'genomics' is now central to many research fields, such as medicine and evolutionary biology, the impact of genetic information on everyday life is growing. Here we will present, discuss, and play around with publicly available genomic information, mostly focussing on the human genome. We will go through multiple open-source tools that can be use to explore and analyse genomic data with nothing more than your own computer. We will also discuss what are the options if you want to build a DNA sequencing laboratory in your garage.